A systems model of health built with AI

Learn about our mission

The biggest challenges we face in the world — from health to climate, migration to income inequality — are systems, yet the knowledge we need to address those challenges is siloed.

We believe that it is time to evolve the way we organize the world’s knowledge: from silos to systems.

So we created System.

Industry news\
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September 24, 2024\
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100+ Experts at Mass General Brigham Identify "A Systems-Level View of Disease" as a Top 10 Unmet Need in Healthcare\
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Read the article

The system of cognitive dysfunction

The changing relationship between climate and health

The system of cognitive dysfunction

The system of cognitive dysfunction

The system of cognitive dysfunction

System Graph

The first quantitative model of the world as one interconnected system

Learn how it works

13,984,366

findings

189 added today

No change

112,372

concepts

No change

No change

4,209,314

relationships

6 added today

No change

Surfaced by the System Graph and extracted from verified sources including peer-reviewed studies and expert-curated databases

As of 10:32pm EST on 11/29/25

Systems in the News

View all

The Guardian\
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September 4, 2025\
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Air pollution can drive devastating forms of dementia, research suggests \
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NYTIMES\
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September 2, 2025\
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Reduced Screening May Have Led to Rise in Advanced Prostate Cancer Diagnoses\
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PBS\
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August 26, 2025\
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Heart disease patients should get vaccinated against respiratory illnesses, including COVID-19, cardiology experts say\
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The Guardian\
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August 24, 2025\
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Exposure to some Pfas could increase risk of multiple miscarriages – study\
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NYTIMES\
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August 19, 2025\
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A Debilitating Virus Surges Globally as Mosquitoes Move With Warming Climate\
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NYTIMES\
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August 17, 2025\
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Wildfire Fighters, Unmasked in Toxic Smoke, Are Getting Sick and Dying\
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NPR\
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July 24, 2025\
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You can't outrun a bad diet. Food — not lack of exercise — fuels obesity, study finds\
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The Guardian\
\
September 4, 2025\
\
Air pollution can drive devastating forms of dementia, research suggests \
\

NYTIMES\
\
September 2, 2025\
\
Reduced Screening May Have Led to Rise in Advanced Prostate Cancer Diagnoses\
\

PBS\
\
August 26, 2025\
\
Heart disease patients should get vaccinated against respiratory illnesses, including COVID-19, cardiology experts say\
\

The Guardian\
\
August 24, 2025\
\
Exposure to some Pfas could increase risk of multiple miscarriages – study\
\

NYTIMES\
\
August 19, 2025\
\
A Debilitating Virus Surges Globally as Mosquitoes Move With Warming Climate\
\

NYTIMES\
\
August 17, 2025\
\
Wildfire Fighters, Unmasked in Toxic Smoke, Are Getting Sick and Dying\
\

NPR\
\
July 24, 2025\
\
You can't outrun a bad diet. Food — not lack of exercise — fuels obesity, study finds\
\

The Guardian\
\
September 4, 2025\
\
Air pollution can drive devastating forms of dementia, research suggests \
\

NYTIMES\
\
September 2, 2025\
\
Reduced Screening May Have Led to Rise in Advanced Prostate Cancer Diagnoses\
\

PBS\
\
August 26, 2025\
\
Heart disease patients should get vaccinated against respiratory illnesses, including COVID-19, cardiology experts say\
\

The Guardian\
\
August 24, 2025\
\
Exposure to some Pfas could increase risk of multiple miscarriages – study\
\

NYTIMES\
\
August 19, 2025\
\
A Debilitating Virus Surges Globally as Mosquitoes Move With Warming Climate\
\

NYTIMES\
\
August 17, 2025\
\
Wildfire Fighters, Unmasked in Toxic Smoke, Are Getting Sick and Dying\
\

NPR\
\
July 24, 2025\
\
You can't outrun a bad diet. Food — not lack of exercise — fuels obesity, study finds\
\

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System API

Build your own apps and models with the System API

Learn more

Case study\
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Integrating the EMBL GWAS Database into the System Graph

"In our AI4HealthyCities initiative, we aim to identify and address the key drivers of cardiovascular health to improve outcomes and inequities. System helps us to quickly synthesize vast amounts of published insights and understand and quantify relationships between determinants and outcomes. In combination with local data, this provides vital information to develop population health roadmaps.”

Peter Speyer

Head of Data & Analytics

The Novartis Foundation

Read the case study

“A detailed assessment was conducted by a clinical team and ranked to evaluate the quality, relevance, and utility of the citations. A key advantage of System lies in its flexibility and robust tooling which enables nuanced customization based on specific needs.”

Julian Baldwin, Rebecca Hyde, Christina Dinh

Atropos Health

Read the case study

"In our AI4HealthyCities initiative, we aim to identify and address the key drivers of cardiovascular health to improve outcomes and inequities. System helps us to quickly synthesize vast amounts of published insights and understand and quantify relationships between determinants and outcomes. In combination with local data, this provides vital information to develop population health roadmaps.”

Peter Speyer

Head of Data & Analytics

The Novartis Foundation

Read the case study

“A detailed assessment was conducted by a clinical team and ranked to evaluate the quality, relevance, and utility of the citations. A key advantage of System lies in its flexibility and robust tooling which enables nuanced customization based on specific needs.”

Julian Baldwin, Rebecca Hyde, Christina Dinh

Atropos Health

Read the case study

"In our AI4HealthyCities initiative, we aim to identify and address the key drivers of cardiovascular health to improve outcomes and inequities. System helps us to quickly synthesize vast amounts of published insights and understand and quantify relationships between determinants and outcomes. In combination with local data, this provides vital information to develop population health roadmaps.”

Peter Speyer

Head of Data & Analytics

The Novartis Foundation

Read the case study

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System Apps

See the whole system®

Apps to advance research and improve decision-making, built on top of the System Graph.

Explore System Apps

WholeHealth \
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Investigate the determinants, interventions, and outcomes for any disease, and explore molecular pathways. Health as one interconnected system. \
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Learn more Synthesis \
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Generate an accurate, transparent, and up-to-date syntheses of the literature for any biomedical topic.\
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Learn more

Case Studies

Systems Thinking

Global Issues

Design

Release Notes

Tech

Press & Events

Announcements

Systems IRL

Oct 2, 2025

System’s Evidence Synthesis Leads in Accuracy

Patrick Wedlock

A blind study that asked clinicians to provide real-world clinical questions and score the accuracy of responses generated by System's Synthesize API

Read more..

Source:

Tech

Oct 2, 2025

Welcoming Dr. Chethan Gangireddy to System as Medical Director

Adam Bly

Dr. Gangireddy’s career spans clinical informatics and cardiology across leading medical institutions like Harvard, University of Pennsylvania, University of Michigan, and Temple University.

Read more..

Source:

Announcements

Sep 15, 2025

System Teams Up with Cornell Tech for Climate Week Hackathon

The Health in Climate Hackathon aims to catalyze innovation at the intersection of climate change and public health.

Read more..

Source:

Global Issues

Press & Events